Dr Moloney and team investigated a surgical technique for Fuchs endothelial dystrophy. Fuchs endothelial dystrophy is a type of corneal disease that affects 1 in 25 people over the age of 40. The condition tends to affect women more than men.
Dr Moloney is a Clinical Senior Lecturer with our Discipline of Ophthalmology.
The treatment by Dr Moloney and his team involves targeted removal of problem areas of the eye. The surgeon strips cells from the eye’s central endothelium, a treatment which aims to reduce the need to rely on corneal transplants. A reduced need for transplants reduces the risk of organ rejection. That’s much better for patients. Also, corneal donations are in short supply.
After treatment, the cornea often regenerates with clearer, healthy tissue. However, more work needs to happen to improve treatment success rates.
For this work, Dr Greg Moloney received the prestigious Troutman Corneal Prize. The Cornea Society makes this award once a year. The award goes to the most innovative paper published by a young investigator.
‘Vitamania’ opens with the story of Cian, a young teenager from Perth. Cian started to lose his vision at 14. He visited many specialists. He had testing for a range of diseases. No one found a cause. At a loss, a family member flew Cian from Perth to Sydney to see Prof Watson.
Professor Watson immediately diagnosed Cian with Vitamin A deficiency. Vitamin A deficiency is a rare diagnosis in developed countries like Australia. In the developed world, Vitamin A deficiency usually occurs after other medical complications. Cian’s Vitamin A deficiency was due to his diet. Cian was a fussy eater; since the age of 5, he had been living on chicken, bread, chips, and coke.
Vitamin A deficiency can lead to blindness, infections and death. Today, 228 million children lack enough Vitamin A. That makes Vitamin A deficiency the most common form of childhood blindness. Vitamin A deficiency causes eye diseases in 5 to 10 million children a year. Of those, five hundred thousand go blind because of a lack of Vitamin A.
Vitamin A, a fat-soluble vitamin, is found in dairy products. Vitamin A also occurs in some fruits and green leafy vegetables. It has two roles in the eye; it helps the retina convert light to a visual signal in the retina. It also ensures correct maturation of the ocular surface cells.
The first sign of vitamin A deficiency is an eye condition called ‘xerophthalmia’. The effects on the eyes of xerophthalmia follow a predictable pattern. The first stage is night blindness (nyctalopia). That’s where retinal rhodopsin (sight pigments) stop regenerating. The second stage is drying (conjunctival xerosis). Corneal drying can lead to ulceration, scarring and keratomalacia. Keratomalacia is a rapidly progressive and irreversible disease that can lead to rupture of the cornea with loss of the eye’s content. Vitamin A deficiency also affects mood and general health with anaemia a frequent association.
In many of these cases, prompt treatment with high doses of Vitamin A can reverse the effects. In Cian’s case, he improved his nutrition and regained sight in his right eye but not his left eye.
In Australia, doctors should examine a patient’s diet if there is an unexplained visual loss.
See the broadcast on SBS Television (Australia) on Sunday, 12 August 2018, at 8:30 pm (in your local timezone).
For those outside of Australia, you can see the movie on Curiosity Stream.
See bonus, online-only interviews with Professor Stephanie Watson after 13 August 2018.
The Save Sight Institute is involved in a new outreach service which recently won a Top End Health Service Quality Award for ‘Improving Elective Surgery Access’.
The QBE Foundation has donated $10,000 to support a unique initiative by Sydney’s Save Sight Institute to assist children and teenagers with low vision or blindness. The “Making Connections” information day was attended by approximately 200 people, including teenagers with vision loss, their parents and teachers. Parents and carer’s of babies and young children with eye disease were also invited to attend.
The Save Sight Institute has released findings from a commissioned report into the socioeconomic impact of low vision and blindness from paediatric eye disease in Australia, highlighting the significant challenges faced by individuals and families affected by childhood blindness, and subsequent economic impacts more broadly